Daily Brain Care

Daily Brain Care is a powerful combination of six functional foods with full-spectrum molecular weight, most concentrated, and highest bioavailable polysaccharides from aloe vera (BiAloe®) and a unique rice bran blend with hundreds of essential phytonutrients, including amino acids, cofactors, vitamins, and secondary metabolites. The patented (60/816,827) calcium silicate clay is a form of bentonite that helps promote detoxification of insecticides, herbicides, poisons, and heavy metals, without interfering with the utilization of vitamins and other micronutrients, through its negative electrical charge binding capacity. The principal structure and function nutrients in Daily Brain Care are a polysaccharide, multi-nutrient complex. Daily Brain Care is doctor formulated and the result of decades of research and scientific investigation. It is superior to the competition for supporting brain health and based on the findings of the clinical research it is arguably the best supplement for the brain.

Benefits of Daily Brain Care for Brain Health and Overall Health

Clinical studies in humans taking Daily Brain Care have shown improvements in: 

  • cognitive function (according to the ADAS-Cog cognition score, which is the gold standard for assessing cognition)
  • immune function (according to the CD4/CD8 ratio, which is an overall indicator of how effective the immune system is working)
  • inflammation (according to TNF-α and VEGF, which are used to assess the body’s response to stress or infection in an inflammatory state)
  • adult stem cells (according to CD14+ cells, which are a marker of how well the body continues to produce stem cells). 

Although not statistically significant, the research also showed that Daily Brain Care caused brain derived neurotrophic factor to modestly increase, which is well known for its critical roles in the brain regions that are involved in neurosynaptic function, apoptosis, plasticity, long-term potentiation, learning memory processes, and higher-order thinking. Thus, compared to other vitamins for the brain, Daily Brain Care has superior efficacy, and it does not contain any caffeine, which is a known stimulant that temporarily creates a sense of focus and well-being, only to subside after its effect wanes.

In addition to Daily Brain Care’s effect on brain health, such as being sharper, more focused, having better memory, and quicker recall, other key benefits have been reported as well. For example, some people report more energy and a better overall sense of well-being, you may notice a quicker recovery from being sick or stressed out, you may start to have longer, deeper, and more refreshing sleep, and you may have a generally happier and more balanced mood. In addition, other people find that they have improved stomach and bowel function, and still other people notice that they have better skin, hair, and nails. Thus, while Daily Brain Care is targeted for people searching for brain health supplements, you can anticipate the possibility of feeling its benefits in other areas, too.

quotes icon
Daily Brain Care is the “Best purchase ever.” After suffering a stroke, I was very weak. I started to take this product and the improvements were amazing in no more than 1 month. 

Nicolas, Miami

Daily Brain Care Ingredients

Daily Brain Care is the best supplement for your brain that is backed by many years of research and is designed to give you significant nutritional support, not only for brain health, but for every cell in your body.  Each ingredient is included for specific reasons to support your health.  Here are some important details about the ingredients in the formula.  

  • BiAloe® is a certified organic aloe polysaccharide that is the most concentrated and bioavailable version on the market.  These polysaccharides are important for all cellular activities, particularly those that lead to optimal immune function.
  • Stabilized Rice Bran contains more than 450 phytonutrients, over 200 of which are amino acids, cofactors, minerals, and vitamins, that have documented health properties.
  • Golden Flaxseed is a significant source of the two parent essential fatty acids, alpha-linolenic acid (omega-3) and linoleic acid (omega-6), that are required for the maintenance of life.  “Essential” means that the human body cannot manufacture or synthesize a nutrient by itself, so it must be obtained from the diet, and the fatty acids found in golden flaxseed support the health of the brain, heart, and blood vessels and can reduce inflammation. Flaxseed is high in a type of polyphenol called lignan that possesses many health-promoting benefits, none the least of which is its ability to reduce the risk of and protect against cancer.
  • Sunflower Lecithin is a fatty natural emulsifier that is rich in choline, which is necessary for brain and heart health, and other essential fatty acids such as phosphatidylinositol, which is important for our metabolism and the structure of all cells.  Sunflower lecithin may support healthy cholesterol and blood pressure levels.
  • Dioscorea supports the synthesis and balance of hormones and may be beneficial for improving your cholesterol levels.  Dioscorea contains a range of nutrients, including fiber, beta carotene, and vitamin C, and it also contains molecules called saponins that may ultimately result in its ability to have a beneficial effect on cholesterol and blood sugar levels, although these findings are preliminary and not well-defined at this time.
  • Tart Cherry is a nutritional dynamo, containing a wide range of nutrients, such as fiber, beta carotene, vitamin C, potassium, manganese, copper, and vitamin K (a very important vitamin for the brain), which are all important for our health.  Consuming tart cherry has been shown in many studies that it helps with insomnia, reduces pain and soreness, and is beneficial for the brain and the immune system.
  • N-Acetyl-Cysteine is a slightly different form of the amino acid, cysteine, thus giving it antioxidant properties as it replenishes cellular levels of glutathione, the human body’s master antioxidant. Taking N-acetyl-cysteine is a primary way to enhance your glutathione level, which is important for counteracting oxidative stress from reactive oxygen species and neutralizing toxic heavy metals and inorganic chemicals.  N-acetyl-cysteine can counteract liver failure from acetaminophen toxicity, and it helps to fight off cases of flu, colds, and lung disease.
  • Calcium Silicate Clay is a patented (60/816,827) form of bentonite that helps promote detoxification of insecticides, herbicides, poisons, and heavy metals, without interfering with the utilization of vitamins and other micronutrients, through its negative electrical charge binding capacity.
  • Inositol Hexaphosphate (IP6) is a vitamin-like phytonutrient that has antioxidant properties, has shown preliminary promise in the way it apparently prevents cancer cell proliferation, and also supports a healthy immune system.
  • Citric Acid is a key intermediary component of the Kreb’s cycle, which occurs in cellular metabolism for energy production in the mitochondria, the engine of your cells.  Citric acid also bonds or chelates to minerals and metals, allowing the body to better absorb such molecules as calcium and potassium.  Thus, Daily Brain Care contains a unique blend of ingredients that has many documented benefits to help you live a healthier life.

Why are Polysaccharides Important?

The field of glycobiology (the study of the biology, biosynthesis, and structure of carbohydrates, saccharides, or sugars) shows us that the process of glycosylation (i.e., the reaction in which a polysaccharide (carbohydrate or sugar) is attached to a protein or fat to form what is called a glycoconjugate) is a very important function in our cells. These glycoconjugates are bioactive compounds that help to guide the way many of our cells function. The cells use these glycoconjugates for many different purposes, including to help regulate our immune system’s function and activity and for cells to communicate with one another. If we do not provide our cells with the needed amounts of polysaccharides in the diet to execute these basic functions, then we are not living optimally. 

The body is smart enough to take other, common simple sugars, like glucose and fructose, which are typically eaten too often, and transform them into the required polysaccharides needed for glycosylation, but this appears to be an inefficient way to enable our cells to function properly. 

Taking Daily Brain Care every day is the best way to ensure that you are getting the right types and amounts of polysaccharides that are so important to not only glycosylation, but supporting all of the body’s functions, and ultimately to allow you to feel healthy.

Summary of Polysaccharide Research

Polysaccharides (sugars with a complex biochemical structure) constitute a class of nutrients that are important for health.  Most importantly, during the second major step of biosynthesis in all cells, nine molecules of mannose, a key polysaccharide found in BiAloe® in Daily Brain Care, are required in the endoplasmic reticulum to initiate the assembly of glycoproteins and glycolipids.  This process demonstrates that polysaccharides are used for glycosylation (i.e., the addition of saccharides to amino acid chains or free fatty acid chains) in the endoplasmic reticulum and the Golgi.  The significance of the coding capacity of polysaccharides in glycoproteins and glycolipids is documented in a series of review articles in Acta Anatomica (Denker, 1998).  The addition of nine molecules of mannose in three chains in the endoplasmic reticulum constitutes the establishment of a domain on which instructions for life processes are transmitted between cells.  In the Golgi, other polysaccharides are added, and the number of mannose units is modified to provide a code of information for conducting host defense, repair, growth, healing, and homeostasis.  This domain is the principal site for coordinating activities for the trillions of cells that make up the human body.

This fundamental supporting biochemistry is why supplying polysaccharides from food sources results in a broad spectrum of health-supporting benefits.  Additionally, concentrated levels of polysaccharides in dietary supplements, like Daily Brain Care, compared to their levels in foods, take advantage of how a concentrated amount of nutrients allows a greater number of bioactive compounds to be created.

As mentioned above, BiAloe® is a very potent aloe polysaccharide, called acemannan or mannose, that has been shown to support the natural biochemical mechanisms of antiviral cells (Kahlon et al., 1991).  In humans, acemannan also supports cell processes that are:  antibacterial, anti-neoplastic, wound healing, intracellular stabilizing, rebalancing and adaptative for stressed cells, and able to increase the synthesis of reduced-glutathione, the principal intracellular antioxidant and multi-systems balancing compound (Dykman & Dykman, 1998; Everson et al., 1992; Kalebic et al., 1991; Lefkowitz et al., 2000; McDaniel, 1987, 1990; McDaniel et al., 2006).  Aloe vera extracts also have fractions with unique molecular and pharmacological profiles, e.g., one fraction displayed hematopoietic activity, while another fraction displayed anti-inflammatory activity, i.e., down-regulation of iNOS and TNF (Kim et al., 1999).

Thus, the documented cellular and physiological effects of the acemannan found in BiAloe® and other polysaccharides in Daily Brain Care are very potent and can help to support brain health, but overall health as well.  If you already have a health challenge, then the use of these polysaccharides is even more important to counteract the complications and symptoms.  The positive effects of these polysaccharides are likely even more potent with an increasing daily dose.  To be sure, supplementing with polysaccharides from different sources provides the opportunity for you to receive a wide range of phytochemicals with multiple health benefits. For more information about the research on polysaccharides, go here.


Denker, H. (1998). Editor’s note. Acta Anatomica, 161, 5.
Dykman, K.D., & Dykman, R.A. (1998). Effect of nutritional supplements on attentional-deficit hyperactivity disorder. Integr Physiol Behav Sci, 33, 49-60.
Everson, G., Daggy, B., McKinley, C., & Story, J. (1992). Effects of psyllium hydrophilic mucilloid on LDL-cholesterol and bile acid synthesis in hypercholesterolemic men. J Lipid Res, 33, 1183-92.
Kahlon, J., Kemp, M., Carpenter, R., McAnalley, B., McDaniel, H.R., & Shannon, W. (1991). Inhibition of AIDS virus replication by acemannan in vitro. Molecular Biotherapy, 3(3), 127-135.
Kalebic, T., Kinter, A., Poli, G., Anderson, M., Meister, A., & Fauci, A. (1991). Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine. Proc Natl Acad Sci U S A, 88(3), 986-990.
Kim, H., Kacew, S., & Lee, B. (1999). In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor). Carcinogenesis, 20, 1637-1640.
Lefkowitz, D., Stuart, R. Gnade, B., Roberts, E., & Lefkowitz, S. (2000). Effects of a glyconutrient on macrophage functions. Int J Immunopharmacol 22, 299-308.
McDaniel, H.R. (1987). Identification of a gigantic circulating monocytic cell in warm blooded animals. Paper presented at the Annual Meeting of the American Society of Clinical Pathology New Orleans, LA.
McDaniel, H.R. (1990). HIV-1 patients respond favorably to oral acemannan. Paper presented at the 6th International Conference on AIDS San Francisco, CA.
McDaniel, H.R., Smith, P., McDaniel, C., & Crenshaw, R. (2006). A multi-site pilot survey of micronutrients in Alzheimer's patients. Paper presented at the 2nd Annual Glycomics Medical Conference: Science of Glycobiology Houston, TX.

Deily Brain Care

Daily Brain Care is clinically proven to support brain health.

Summary of Memory-Related Research

Neurodegenerative disorders are rampant today, they are increasing, and they are not effectively treated by conventional medicine.  The United States currently has approximately 14 million Americans with some type of dementia and about 6 million of those have Alzheimer’s.  Alzheimer’s is currently the 6th leading killer of Americans, has no known preventative strategy, and conventional medicine can do virtually nothing but delay the inevitable decline for a few months with the five FDA-approved medications for dementia.  In addition, Parkinson’s disease and multiple sclerosis are the two other leading neurodegenerative disorders affecting millions more Americans.

Our lab conducted some very exciting research among a sample of people with moderate to severe memory disorder.  All subjects in the study had been diagnosed with the disorder for a minimum of one year and for an average of about 3 years, and we assessed their cognitive function at baseline and every 3 months for 12 months.  Also, we drew their blood to assess immune system functioning and markers of inflammation.  We wanted to assess the relationships between immune function and cognition over the course of the study.  Each subject took 4 scoops per day of Daily Brain Care for the entire 12 months of the study.

What we discovered at the end of the study was nothing short of remarkable.  Our team demonstrated in memory disorder patients perhaps for the first time: (1) significant and sustained improvements in cognitive function over a one-year period; (2) a significant improvement in overall immune function; (3) a significant improvement in inflammatory status, which may lead to reduced neuroinflammation; (4) a significant increase in the production of stem cells, which may lead to repair of affected neuronal areas; and (5) a correlation between clinical (cognitive) and physiological (immune) function (Lewis et al., 2013)!  Our results were truly astounding, and to date they have not been exceeded by any nutritional or pharmaceutical product.  Additionally, I want to be clear that the study demonstrates the power and capability of nutrition.  We did NOT treat, cure, manage, or mitigate disease, but we showed the ability of the body to repair and regenerate itself when given the proper raw materials (i.e., nutrients) to do so.  This is the power of nutrition and is part of a fundamental principle that says that supplying the body the nutrients it needs that are typically missing in the diet today will allow the body to heal itself. For more information about the research on polysaccharides in people with memory dysfunction, go here.


Lewis, J.E., McDaniel, H.R., Agronin, M., Loewenstein, D., Riveros, J., Mestre, R., Martinez, M., Colina, N., Abreu, D., Konefal, J., Woolger, J.M., & Ali, K.H. (2013). The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer’s disease. The Journal of Alzheimer’s Disease, 33, 393-406.

quotes icon
Since taking Daily Brain for about 6 months, my hair and nails are the healthiest they have ever been. I have a multi-nodular goiter, and the nodules have reduced according to my last sonogram.

Mercy, Miami

How Does Daily Brain Care Compare to Other Brain Health Supplements and Medications for Memory Problems?

Daily Brain Care has a distinct competitive advantage as the best brain health supplement over the rest of the products in the brain health or nootropic space in the dietary supplement industry:  a 12-month clinical trial that was conducted in patients with a memory disorder and cognitive dysfunction showing clinically and statistically significant improvements in cognition and immune functioning without significant side effects.  To our knowledge, no other product can match our levels of effectiveness according to the results of our findings (Lewis et al., 2013; Martin et al., 2017; Stillman et al., 2019)!

Nonetheless, quite a few other studies in cognitive functioning have been conducted on two dietary compounds:  Gingko biloba and vitamin E.  For example, a meta-analysis among studies of Alzheimer's patients taking 120 to 240 mg of Gingko biloba for 3- to 6-month treatment periods revealed a small though statistically significant effect on objective measures of cognitive function (Oken et al., 1998).  However, a study by Solomon et al. (2002) revealed that Gingko biloba, when taken following manufacturer’s instructions, had no beneficial effect on memory and related mental functions in 230 physically and mentally healthy adults over the age of 60.  While central nervous system oxidative stress has been theorized as a possible cause for Alzheimer's and dementia, researchers have found protective effects of vitamins E and C against cognitive decline (Paleologos et al., 1998; Perrig et al., 1997).  Others found that 2,000 IU of vitamin E slowed the progression of moderately severe Alzheimer's in a group of patients, but no changes in cognitive functioning were found (Sano et al., 1997).

Meanwhile, five FDA-approved medications are prescribed for dementia and Alzheimer's patients.  Although Daily Brain Care is a dietary supplement and not regulated by the FDA as a drug, it might be useful to mention these compounds as competitors.  For the early to moderate stages of Alzheimer's, the cholinesterase inhibitors are used:  Aricept (donepezil), Exelon (rivastigmine), and Razadyne (galantamine).  These drugs are used to treat symptoms related to cognitive functioning, may help delay symptoms or slow them from worsening for a limited time, are not particularly efficacious, and as with all drugs have significant side effects.  For moderate to severe stages of Alzheimer's, Namenda (memantine), Aricept (donepezil), and Namzaric (a combination of Namenda and Aricept) are the drugs prescribed, with Namenda being the most common.  Namenda might temporarily improve some aspects of cognitive functioning, but will decline in efficacy over time and also has significant adverse effects.


Lewis, J.E., McDaniel, H.R., Agronin, M., Loewenstein, D., Riveros, J., Mestre, R., Martinez, M., Colina, N., Abreu, D., Konefal, J., Woolger, J.M., & Ali, K.H. (2013). The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer’s disease. The Journal of Alzheimer’s Disease, 33, 393-406.
Martin, A., Stillman, J., Miguez, M-J., McDaniel, H.R., Konefal, J., Woolger, J., & Lewis, J.E. (2017). The effect of dietary supplementation on brain-derived neurotrophic factor and cognitive functioning in Alzheimer’s dementia. Journal of Clinical and Translational Research, 3(3), 1-6.
Oken, B.S., Storzbach, D.M., & Kaye, J.A. (1998). The efficacy of ginkgo biloba on cognitive function in Alzheimer's disease. Archives of Neurology, 55, 1409-1415.
Paleologos, M., Cumming, R., & Lazarus, R. (1998). Cohort study of vitamin c intake and cognitive impairment. American Journal of Epidemiology, 148, 45-50.
Perrig, W., Perrig, P., & Stahelin, H. (1997). The relation between antioxidants and memory performance in the old and very old. Journal of the American Geriatric Society, 45, 718-724.
Sano, M., Ernesto, C., Thomas, R.G., Klauber, M.R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C.W., Pfeiffer, E., Schneider, L.S., & Thal, L.J. (1997). A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease. The New England Journal of Medicine, 33(6), 1216-1222.
Solomon, P.R., Adams, F., Silver, A., Zimmer, J. & DeVeaux, R. (2002). Ginkgo for memory enhancement: a randomized controlled trial. Journal of the American Medical Association, 288, 835-840.
Stillman, J., Martin, A., Miguez, M.J., McDaniel, H.R., Konefal, J., Woolger, J.M., & Lewis, J. E. (2019). Relationship between brain-derived neurotrophic factor and immune function during dietary supplement treatment of elderly with Alzheimer’s dementia. Journal of Clinical and Translational Research. 5(2), 68-75.

Newsletter Signup